在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ME1 Antibody

  • 中文名稱:
    ME1兔多克隆抗體
  • 貨號(hào):
    CSB-PA269233
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA269233(ME1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA269233(ME1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: CSB-PA269233(ME1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cytosolic malic enzyme 1 antibody; HUMNDME antibody; Malate dehydrogenase antibody; Malic enzyme 1 antibody; Malic enzyme 1; NADP(+) dependent; cytosolic antibody; Malic enzyme 1; soluble antibody; Malic enzyme; cytoplasmic antibody; MAOX_HUMAN antibody; ME1 antibody; MES antibody; NADP dependent malic enzyme antibody; NADP ME antibody; NADP-dependent malic enzyme antibody; NADP-ME antibody; Pyruvic malic carboxylase antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human ME1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. Bioinformatics analysis identified that miR612 targeted ME1, which expression was high and inversely associated with miR612 expression in bladder cancer tissues. PMID: 29620192
    2. Findings indicate that malic enzyme 1 (ME1) is a valid target for molecular therapy in oral squamous cell carcinomas (OSCCs). PMID: 29601126
    3. these findings uncover a direct cross-talk mechanism between ME1 and PPP, may reveal an alternative model for signaling transduction via protein conformational simulation, and pave the way for better understanding how metabolic pathways are coordinated in cancer. PMID: 28848047
    4. ME1/ME2 expression phenotype may have a potential to be a valuable marker for sebaceous differentiation in sebaceous lesions. PMID: 26381116
    5. ME1 expression was found to be mutant-KRAS-associated in NSCLC cancer cell lines. Patients with elevated ME1 had worse outcomes after radiotherapy. Transamination generating cytosolic NADPH via ME1 may contribute to radioresistance. PMID: 26173780
    6. ME1 overexpression associates with unfavorable prognoses in patients with HCC, suggesting that ME1 is a poor prognostic predictor of hepatocellular carcinoma. PMID: 25753478
    7. essential role for ME1 in the production of cytosolic NADPH and maintenance of migratory and invasive abilities of nasopharyngeal carcinoma cells PMID: 23114090
    8. the differential protein stability between dimer and tetramer interface interactions of human c-NADP-ME PMID: 23284632
    9. p53 represses the expression of the tricarboxylic-acid-cycle-associated malic enzymes ME1 and ME2 in human and mouse cells PMID: 23334421
    10. cytosolic malic enzyme 1 gene polymorphism is associated with the degree of suppression of parathyroid hormone after long-term calcium supplementation; the effect is probably mediated through an increase in intestinal calcium absorption PMID: 22456781
    11. ME1 is a functional target gene of the BACH1 transcription factor according to ChIP-seq and knockdown analysis in HEK 293 cells. PMID: 21555518
    12. that the single mutation of Gln362 to Lys in human m-NAD-ME changes it to an NADP+-dependent enzyme, which is characteristic because it is non-allosteric, non-cooperative, and NADP+-specific PMID: 16757477
    13. although ME1 overexpression augments anaplerosis and glucose stimulated insulin secretion in INS-1 832/13 cells, it is not likely involved in methyl succinate and glucose stimulated insulin secretion in pancreatic islets PMID: 19293334
    14. human c-NADP-ME exists mainly as a tetramer, whereas human m-NAD(P)-ME exists as a mixture of dimers and tetramers PMID: 19416979
    15. A series of R98/D102 mutants examined the possible interactions between Arg98 and Asp102 using double-mutant cycle analysis. Kinetic analysis revealed that the catalytic efficiency of was severely affected by mutating both Arg98 and Asp102 residues. PMID: 19464998

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm.
  • 蛋白家族:
    Malic enzymes family
  • 組織特異性:
    Expressed in all tissues tested including liver, placenta and white adipose tissue.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6983

    OMIM: 154250

    KEGG: hsa:4199

    STRING: 9606.ENSP00000358719

    UniGene: Hs.21160



主站蜘蛛池模板: 青青青国产在线视频在线观看| 日本妇人成熟免费| 国产精品嫩草影院av| 国产成人精品.视频| 丁香五月综合久久激情| 亚洲精品国产av成拍色拍婷婷 | 狠狠色丁香久久婷婷综合五月 | 日本一区二区无卡高清视频| 欧美激欧美啪啪片| 国产精品a无线| 国产又猛又黄又爽| 亚洲成在人线在线播放无码vr| 极品美女扒开粉嫩小泬图片| 99久热re在线精品99re8热视频 | 中文字幕av伊人av无码av狼人| 中文国产成人精品久久app| 狠狠色婷婷久久一区二区三区| 国产午夜亚洲精品不卡| 国内精品乱码卡一卡2卡| 欧美日本日韩| 瑜伽裤国产一区二区三区| 欧美成人精精品一区二区| 国内熟妇人妻色无码视频在线| 无码人妻一区二区三区免费看成人| 人人妻人人藻人人爽欧美一区| 日产乱码一区二区三区在线| 四虎永久在线精品免费无码| 久久久久亚洲精品| 老子午夜精品无码不卡| 浪荡女天天不停挨cao日常视频| 欧美视频网站www色| 一个人看的www视频免费观看 | 污污又黄又爽免费的网站| 无码人妻久久一区二区三区app| 亚洲成a人v欧美综合天堂麻豆| 亚洲gv猛男gv无码男同| 日本亲子乱子伦xxxx50路| 亚洲日韩一区二区| 丰满岳跪趴高撅肥臀尤物在线观看| 狼友av永久网站免费观看孕交 | 日本亚洲欧美高清专区vr专区|